Professor Martin Grootveld
Professional biography:
After first graduating in Chemistry/Statistical Analysis at Birkbeck College, University of London (part-time whist working as a medical laboratory scientific officer at Guy's Hospital Poisons Unit), Prof. Grootveld completed his Ph.D degree research on metallodrugs in 1985 at the same institution and then conducted post-doctoral work on free radical biochemistry at King's College, University of London for 2 years. He then spent 21/2 years lecturing and conducting research work at the Polytechnic of North London prior to taking up a Lectureship in Clinical Chemistry at the Royal London Hospital Medical College in 1989, where he subsequently became Senior Lecturer and then Reader in Chemical Pathology. Later, he transferred to London South Bank University where he was also Reader in Chemical Pathology, and Director of their M.Sc Forensic Science course. He is now Professor of Biochemistry and Biomedical Materials at the University of Bolton, and was Visiting Professor in Clinical Chemistry at Queen's University Belfast from 2001-2005. Prof. Grootveld is the author of almost 100 full, refereed research publications in reputable international scientific and/or clinical journals, 20 reviews and more than 150 refereed conference contributions. He has attracted more than £4,000,000 of external research funding since 1987 (from research councils, medical charities, the European Union, industry, etc.). Prof. Grootveld also organised and chaired the very first international symposium regarding the applications of high-resolution NMR techniques to the oral science area (IADR conference, New Orleans, USA, March 2007).
Current research interests:
The multicomponent high-resolution NMR analysis of biofluids and further complex samples
The development and application of techniques for the monitoring of drugs of both clinical and forensic interest
Synthesis, applications and mechanisms of action of drugs and metallodrugs
Pharmacology and pharmacodynamics
The biological and medicinal chemistry of reactive oxygen species, together with the detection and pathological significance of products derived from these processes, both in vitro and in vivo
Biological inorganic chemistry
The development and testing of novel biomaterials and biosensors Bio- and chemometrics.
Selected recent publications:
Siddiqui, N., Sim, J., Silwood, C.J.L., Toms, H., Iles, R.A., Grootveld, M. Multicomponent analysis of encapsulated marine oil supplements using high resolution 1H and 13C NMR nuclear magnetic resonance (NMR) techniques. Journal of Lipid Research 2003; 44: 2406-2427.
Grootveld, M., Silwood, C.J.L. 1H NMR analysis as an analytical probe for human saliva. Biochemical and Biophysical Research Communications 2005; 329: 1-5.
Silwood, C.J.L., Grootveld, M. Chemical nature of implant-derived titanium(IV) ions in synovial fluid. Biochemical and Biophysical Research Communications 2005; 330: 784-790.
Silwood, C.J.L., Grootveld, M. Examination of the molecular nature of low-molecular-mass chromium(III) ions in isolated osteoarthritic synovial fluid. Journal of Inorganic Biochemistry 2005; 99: 1390-1400.
Silwood, C.J.L., Grootveld, M. Evaluation of the speciation status of aluminium(III) ions in isolated osteoarthritic knee-joint synovial fluid. Biochimica et Biophysica Acta 2005; 1727: 327-339.
Silwood, C.J.L., Abrahams, I., Apperley, D.C., Lockyer, N.P., Lynch, E., Motevalli, M., Nix, R.M.,Grootveld, M. Surface analysis of novel hydroxyapatite bioceramics containing titanium(IV) and fluoride. Journal of Materials Chemistry (Royal Society of Chemistry) 2005; 15: 1626-1636.Advanced article DOI; 10.1039/b417539e.
Silwood, C.J.L, Grootveld, M. 1H and 51V NMR investigations of the molecular nature of implant-derived vanadium ions in osteoarthritic knee-joint synovial fluid. Clinica Chimica Acta 2007; 380(1-2): 89-99.